Discovering The Developmental Origins of Obesity

The Polish Academy of Sciences in Olsztyn, Poland


Scarless skin wound healing in FOXN1 deficient (nude) mice is associated with distinctive matrix metalloproteinase expression

Barbara Gawronska-Kozak1

Regenerative Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland

Keywords: Matrix metalloproteinases, Wound healing, Regeneration, FOXN1, Nude mice

Similar to mammalian fetuses FOXN1 deficient (nude) mice are able to restore the structure and integrity of injured skin in a scarless healing process by mechanisms independent of the genetic background. Matrix metalloproteinases (MMPs) are required for regular skin wound healing and the distinctive pattern of their expression has been implicated to promote scarless healing. In this study, we analyzed the temporal and spatial expression patterns of these molecules during the incisional skin wounds in adult nude mice. Macroscopic and histological analyses of skin wounds revealed an accelerated wound healing process, minimal granulation tissue formation and markedly diminished scarring in nude mice.