Discovering The Developmental Origins of Obesity

The Polish Academy of Sciences in Olsztyn, Poland


Leslie P. Kozak, Prof.

 prof kozak



Leslie P. Kozak



From January 1, 2011:
Institute of Animal Reproduction and Food Research
Polish Academy of Sciences
ul. Tuwima 10
10-747 Olsztyn, Poland


From January 1, 2011:
ul. Jagiellonska 55D m 3
10-292 Olsztyn, Poland


Date and Birth place:
October 28, 1940; Manitoba, Canada


St. John Fisher College, Rochester, NY, 1964
University of Notre Dame, Chemistry, Biochemistry, 1969


Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland
  • Professor, 2011-present
Pennington Biomedical Research Center,
  • Professor, 1998-2010
  • C. B. Pennington Jr. Chair of Molecular Genetics, 1998-present
  • Chief of the Division of Experimental Obesity, 2001-2003
The Jackson Laboratory, Bar Harbor, ME,
  • Associate Staff Scientist, 1970-1974
  • Staff Scientist, 1974-1980
  • Senior Staff Scientist, 1980-1998
  • Assistant Director (Training), 1978-1980
  • Deputy Director, 1984-1988
University of Aarhus, Denmark, Lecturer, Institute of Ecology & Genetics, 1980

Michigan State University, Research Associate, 1968-1970

University of Notre Dame, Graduate Assistant, 1964-1967


USPHS Pre-doctoral Fellow, 1967-1968 


American Society for Biochemistry and Molecular Biology 
North American Association for the Study of Obesity 


Journal of Experimental Zoology, Associate Editor, 1974-1978 
Archives of Biochemistry and Physics, Editorial Board, 1981-1984 
Journal of Neuroscience, Editorial Board, 1986-1989 
The Journal of Biological Chemistry, Editorial Board,
  • July 1, 1998 - 2003;
  • July 1, 2009 - 2014 
  • NIH Biomedical Sciences, Ad hoc, September 1983
  • NIH Biomedical Sciences, Ad hoc, May 1984
  • NIH Mammalian Genetics, Ad hoc, February 1986
  • NIH Mammalian Genetics, Ad hoc, April 1986
  • NIH Molecular Cytology, Ad hoc, June 1986
  • NIH Biomedical Sciences, Member, 1989-1993
  • NIH Metabolism Study Section, October 23-24, 2003
  • NIH IPOD Ad hoc, February, 201


  1. University of Pennsylvania, Department of Biochemistry and Biophysics.  Seminars in Obesity Research, Invited Speaker.  Thermogenesis, uncoupling proteins and the regulation of body weight. Philadelphia, PA  4/28/98
  2. FASEB Meeting New Orleans, LA.  5/19/98
  3. 8th International Congress on Obesity, Plenary Lecture, Genetic Control of Brown Adipocyte Induction.  Paris, France,  9/3/98
  4. 71st Annual Meeting of the American Thyroid Association.  Invited Speaker, Role of uncoupling proteins in thermogenesis and energy balance: Insights from transgenic models.  Portland Oregon,  9/17/98
  5. 10th Naito Conference on the Molecular Biological Approaches for Intractable Diseases.  Invited Speaker, Exploring the role of the mitochondrial uncoupling proteins and brown adipocytes in the regulation of body weight.  Kanagawa, Japan.  10/30/98
  6. Quebec Conference on Uncoupling Proteins and Obesity.  Invited Speaker.   Mitochondrial uncoupling proteins and obesity: molecular and genetic aspects of UCP1.  Quebec, Quebec, Canada,  11/20/98
  7. Steenbock Symposium of Adipocyte Biology and Hormonal Signaling.  Invited Speaker.  Exploring a role for brown fat in the regulation of body weight. University of Wisconsin, Madison,  6/6/99
  8. American Diabetes Association, 59th Annual Meeting. Invited Speaker.  Leptin and uncoupling proteins in diabetes. San Diego, CA,  6/20/99
  9. 4th International Smolenice Insulin Symposium on Lipids and Insulin Resistance, Invited Speaker, Transgenic models of diabetes and obesity. 8/29/01
  10. Keystone Symposium, Molecular Control of Adipogenesis and Obesity. Invited Speaker. Genetic Determinants of Thermogenesis and Obesity. 1/10/02.
  11. MARS Nutrition Research Council Annual Meeting. Invited Speaker. Genomics and Thermogenesis. 1/30/02
  12. University of California, Davis. Rowe Program in Human Genetics. Invited Speaker.           uman HhQTL analysis of Ucp1 mRNA production in white fat: genetic and genomic tools for characterization of candidate genes. 5/29/02.
  13. 9th International Congress on Obesity.  San Paulo. Brazil. Invited Speaker. Genetics of Brown Adipose Tissue Development. 8/24/02
  14. Pfizer Corporation, seminar speaker.  9/23/02
  15. Keystone Symposium, Obesity: New Insights into pathogenesis and treatment. Invited Speaker. Thermogenic mechanisms of body weight regulation. 1/21/03.
  16. Invited Seminar, Department of Pharmacology, New Orleans School of Medicine, Louisiana State University. Dissecting regulatory networks controlling the induction of brown adipocytes. 3/18/03.
  17. Invited speaker, American Chemical Society National Meeting, New Orleans. Overview of obesity research: Common Effectors of energy intake and energy expenditure. March 23, 2003.
  18. Invited speaker, Stock conference, Libson, Portugual, Mouse genetics and energy balance.   March 24, 2003.
  19. Invited participant and speaker, NICHD/NIDDK Research Planning Workshop on the Metabolic Syndrome in Children. Washington DC. June 30, 2003.
  20. Invited seminar speaker, Genetic variation in regulatory pathways associated with brown adipocyte function. Cambridge University, September 8 , 2003
  21. Invited seminar speaker, Institute of reproductive and developmental biology, Imperial College, London, September 9, 2003.
  22. Invited seminar speaker, Department of Physiology, University of Turku, Finland, September 11, 2003.
  23. Invited speaker, 2003 Levine Symposium, UCP1-independent mechanism of thermogenesis and body weight regulation, Los Angeles, November 5, 2003
  24. Invited speaker, Keystone Symposium, Molecular Control of Adipogenesis and Obesity, Genetic variation in regulatory pathways associated with brown adipocyte induction. Banff, Canada,  March 8, 2004
  25. Invited speaker, European Congress of Obesity, Prague, Czech Republic, Transdifferentiation of white into brown fat cell: does it exist?  Round table presenter for the con position. May 27,2004.
  26. Invited Speaker, ENDO 2004, New Orleans, Symposium on Energy Expenditure/Thermogenesis, UCP1-independent thermogenesis and the regulation of body weight. June 19, 2004
  27. Invited speaker. Juan March workshop on uncoupling proteins. Current Status and Therapeutic Prospects. Madrid, Spain. April 3, 2005.
  28. Invited speaker. American Diabetes Association, San Diego. Identification of UCP1-independent thermogenic mechanisms regulating body weight using mouse mutants. June 13, 2005.
  29. Invited speaker. Canadian Federation of Biological Societies, Northern Lights Summer Conference. An epigenetic mechanism for diet-induced obesity. June 23, 2005.
  30. Invited speaker.  134th Alfred Nobel Symposium “The Adipocyte a Multifunctional Cell”. Goteburg, Sweden. August 7, 2006.
  31. Invited speaker.  11th Adiposcience Sympsiu, Osaka, Japan.  August 19, 2006.
  32. Invited speaker.  Chubu University, Nagoya, Japan.  August 23, 2006.
  33. Invited speaker. University of Illinois, Champaign, IL.  November 15, 2006.
  34. Invited speaker. Jackson Laboratory’s Discover Strategies Conference: Modeling Human Metabolic Syndrome and Type 2 Diabetes in Rodents. Bar Harbor, ME.  August 5, 2007.
  35. Invited speaker.  University of Ann Arbor.  Ann Arbor, MI.  October 10, 2007.
  36. Invited Speaker. Gerontology Society of America, San Francisco, November 2007.
  37. Invited Speaker. UAB’s Clinical Nutrition Center. Programming of Diet-Induced Obesity. Birmingham, AL. November 11, 2008.
  38. Invited Speaker. NIH Workshop on Human Brown Adipose Tissue, April 29, 2009.
  39. Invited Speaker. Novartis.  Boston, MA. May 15, 2009.
  40. Invited Speaker. 49th Teratology Society Annual Meeting. Rio Grande, Puerto Rico. June 29, 2009.
  41. Invited speaker,  The 11th Annual International Symposium in Obesity, “Rediscovering Brown Adipose Tissue” Quebec City, November 6, 2009
  42. Invited Speaker, Maine Medical Research Center Institute, The Nutritional Environment during Early Development determines the Capacity for  Adipose tissue Expansion & Much more, Portland, ME, August, 2010.
  43. Invited Speaker, Ohio  State University, Inner mitochondrial membrane transporters and metabolic efficiency, Columbus, Ohio, November 2010.
  44. Invited Plenary Speaker, CECON 3rd Olsztyn, The Nutritional Environment during Early Development Determines the Capacity for  Adipose tissue Expansion, Olsztyn, Poland, August 2011.


D. Joseph Jerry, PhD, Associate Professor of Veterinary and Animal Sciences, University of Mass
Michael Kotarski, PhD, Associate Professor, University of Niagara
Anders Jacobsson, PhD, Wenner Gren Institute, Sweden
Bert Boyer, PhD, University of Alaska, USA
Jan Kopecky, MD-PhD, Institute for Physiology, Czech Republic
Sven Enerbäck, MD-PhD, University of Gothenburg, Sweden
Carmen Guerra, PhD, National Center for Oncological Investigations, Madrid, Spain
Hitoshi Yamashita, PHD, Department of Biomedical Sciences, Chubu University, Japan
Robert Koza, PhD, Pennington Biomedical Research Center, USA
Xiaotuan Liu, PhD, Research associate in Baton Rouge, China
Ann Coulter, PhD, Pennington Biomedical Research Center, USA
Wolfgang Hofman, PhD, Roche Biotechnology, Austria
Martin Rossmeisl, PhD, Institute for Physiology, Czech Republic
Jong Rim, Nupotential Inc., PhD, Baton Rouge, LA. Korea
Bingzhong Xue, PhD, Wake Forest University, China
D Grawnke, PhD, Director of training program in bioinformatics, Northwestern Univ.
J Ukropec, PhD, Institute of Experimental Endocrinology, Slovak Academy of Sciences
J Hogan, PhD, Assistant Professor, Central Virginia Community College
Monika Kaczmarek, PhD, Polish Academy of Sciences, Poland
R Anunciado, DVM-PhD, Genetics Training Coordinator, Hudson, NY


  1. Kozak LP, Bretthauer RK. 1968. Synthesis of exocellular phosphomannan by protoplasts of Hansenula holstii. Arch Biochem Biophys 126:764-70.
  2. Bretthauer RK, Kozak LP, Irwin WE. 1969. Phosphate and mannose transfer from guanosine diphosphate mannose to yeast mannan acceptors. Biochem Biophys Res Commun 37:820-7.
  3. Kozak LP, Wells WW. 1969. Effect of galactose on energy and phospholipid metabolism in the chick brain. Arch Biochem Biophys 135:371-7.
  4. Kozak LP, Bretthauer RK. 1970. Studies on the biosynthesis of Hansenula holstii mannans from guanosine diphosphate mannose. Biochemistry 9:1115-22.
  5. Kozak LP, Wells WW. 1971. Studies on the metabolic determinants of D-galactose-induced neurotoxicity in the chick. J Neurochem 18:2217-28.
  6. Granett SE, Kozak LP, McIntyre JP, Wells WW. 1972. Studies on cerebral energy metabolism during the course of galactose neurotoxicity in chicks. J Neurochem 19:1659-70.
  7. Kozak LP. 1972. Genetic control of alpha-glycerolphosphate dehydrogenase in mouse brain. Proc Natl Acad Sci USA 69:3170-4.
  8. Wells WW, Knull HR, Kozak LP. 1972. Galactose toxicity in the chick: hyperosmolality or depressed energy reserves? Science 176:815-6.
  9. Kozak LP. 1974. Purification and characterization of two allelic forms of L-glycerol 3-phosphate dehydrogenase from inbred strains of mice. Biochem Genet 12:69-79.
  10. Kozak LP, McLean GK, Eicher EM. 1974. X linkage of phosphoglycerate kinase in the mouse. Biochem Genet 11:41-7.
  11. Kozak LP, Jensen JT. 1974. Genetic and developmental control of multiple forms of L-glycerol 3-phosphate dehydrogenase. J Biol Chem 249:7775-81.
  12. Kozak LP, Erdelsky KJ. 1975. The genetics and developmental regulation of L-glycerol 3-phosphate dehydrogenase. J Cell Physiol 85:437-47.
  13. Kozak LP, Quinn PJ. 1975. Evidence for dosage compensation of an X-linked gene in the 6-day embryo of the mouse. Dev Biol 45:65-73.
  14. Quinn P, Kozak LP. 1975. Proceedings: activity of certain glycolytic enzymes in developing mouse embryos. J Reprod Fertil 43:388-9.
  15. Kozak LP, Murphy ED. 1976. The reversible expression of an adult isozyme locus, Gdc-1, in tumors of the mouse. Cancer Res 36:3711-7.
  16. Eppig JJ, Kozak LP, Eicher EM, Stevens LC. 1977. Ovarian teratomas in mice are derived from oocytes that have completed the first meiotic division. Nature 269:517-8.
  17. Kozak LP. 1977. The transition from embryonic to adult isozyme expression in reaggregating cell cultures of mouse brain. Dev Biol 55:160-9.
  18. Kozak LP, Eppig JJ, Dahl D, Bignami A. 1977. Ultrastructural and immunohistological characterization of a cell culture model for the study of neuronal-glial interactions. Dev Biol 59:206-27.
  19. Kozak LP. 1978. Increased synthesis of L-glycerol 3-phosphate dehydroenase during in vitro differentiation of reaggregating cerebellar cells. Dev Biol 66:593-600.
  20. Kozak LP, Dahl D, Bignami A. 1978. Glial fibrillary acidic protein in reaggregating and monolayer cultures of fetal mouse cerebral hemispheres. Brain Res 150:631-7.
  21. Kozak LP, Eppig JJ, Dahl D, Bignami A. 1978. Enhanced neuronal expression in reaggregating cells of mouse cerebellum cultured in the presence of poly-L-lysine. Dev Biol 64:252-64.
  22. Kozak, LP. 1978. An analysis of differentiation in coaggregation cultures between mouse neuronal and tumor cells. Basic Life Sci 12:81-95.
  23. Kozak LP. 1979. Coaggregation with tumor cells inhibits expression by cerebellar cells of the adult isozyme locus, Gdc-1. Dev Biol 68:407-21.
  24. Kozak LP, Ratner PL. 1980. Genetic regulation of translatable mRNA levels for mouse sn-glycerol-3-phosphate dehydrogenase during development of the cerebellum. J Biol Chem 255:7589-94.
  25. Fisher M, Gapp DA, Kozak LP. 1981. Immunohistochemical localization of sn-glycerol-3-phosphate dehydrogenase in Bergmann glia and oligodendroglia in the mouse cerebellum. Brain Res 227:341-54.
  26. Kozak LP, Burkart D. 1981. Immunoisolation and the structural analysis of the sn-glycerol-3-phosphate dehydrogenase isozymes in mouse brain. J Biol Chem 256:5162-9.
  27. Ratner PL, Fisher M, Burkart D, Cook JR, Kozak LP. 1981. The role of mRNA levels and cellular localization in controlling sn-glycerol-3-phosphate dehydrogenase expression in tissues of the mouse. J Biol Chem 256:3576-9.
  28. Cook JR, Kozak LP. 1982. Sn-glycerol-3-phosphate dehydrogenase gene expression during mouse adipocyte development in vivo. Dev Biol 92:440-8.
  29. Kozak LP, Burkart DL, Hjorth JP. 1982. Unlinked structural genes for isozymes of sn-glycerol-3-phosphate dehydrogenase in mice. Dev Genet 3:1-6.
  30. Kozak LP, Birkenmeier EH. 1983. Mouse sn-glycerol-3-phosphate dehydrogenase: molecular cloning and genetic mapping of a cDNA sequence. Proc Natl Acad Sci USA 80:3020-4.
  31. Jacobsson A, Stadler U, Glotzer MA, Kozak LP. 1985. Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression. J Biol Chem 260:16250-4.
  32. Kozak LP. 1985. Interacting genes control glycerol-3-phosphate dehydrogenase expression in developing cerebellum of the mouse. Genetics 110:123-43.
  33. Pittler SJ, Kozak LP, Wilson JE. 1985. In vitro synthesis of rat brain hexokinase. Biochim Biophys Acta 843:186-92.
  34. Kozak, LP. 1985. Genetic variation in catecholamine responsive metabolic pathways-a hypothesis for a common regulatory mechanism in BALB/c sublines. Curr Top Microbiol Immunol 122:66-70.
  35. Cook JR, Stadler U, Burkart D, Kozak LP. 1986. Genetic regulation of sn-glycerol-3-phosphate dehydrogenase in brown adipose tissue. Genetics 114:567-78.
  36. Ireland RC, Kotarski MA, Johnston LA, Stadler U, Birkenmeier E, Kozak LP. 1986. Primary structure of the mouse glycerol-3-phosphate dehydrogenase gene. J Biol Chem 261:11779-85.
  37. Kozak LP, Britton JH, Kozak UC, Wells JM. 1988. The mitochondrial uncoupling protein gene: correlation of exon structure to transmembrane domains. J Biol Chem 263:12274-7.
  38. Hirning U, Schmid P, Schulz WA, Kozak LP, Hameister H. 1989. In developing brown adipose tissue c-Myc protooncogene expression is restricted to early differentiation stages. Cell Diff Dev 27:243-8.
  39. Johnston LA, Kotarski MA, Jerry DJ, Kozak LP. 1989. A ubiquitously expressed gene 3.5 kilobases upstream from the glycerol-3-phosphate dehydrogenase gene in mouse. Mol Cell Biol 9:935-45.
  40. Prochazka M, Kozak UC, Kozak LP. 1989. A glycerol-3-phosphate dehydrogenase null mutant in BALB/cHeA mice. J Biol Chem 264:4679-83.
  41. Sugisaki T, Noguchi T, Beamer WG, Kozak LP. 1991. Genetic hypothyroid mice: normal cerebellar morphology but altered glycerol-3-phosphate dehydrogenase in Bergmann glia. J Neurosci 11:2614-21.
  42. Boyer B, Kozak LP. 1991. The mitochondrial uncoupling protein gene in brown fat: Correlation between DNase 1 hypersensitivity and expression in transgenic mice. Mol Cell Biol 11:4147-56.
  43. Kozak LP, Kozak UC, Clarke GT. 1991. Abnormal brown and white fat development in transgenic mice over-expressing glycerol-3-phosphate dehydrogenase. Genes Dev 5:2256-64.
  44. Kozak UC, Held W, Kreutter D, Kozak LP. 1992. Adrenergic regulation of the uncoupling protein gene in brown fat tumor cells. Mol Endocrinol 6:763-72.
  45. Lowell BB, S-Susulic V, Hamann A, Lawitts JA, Himms-Hagen J, Boyer BB, Kozak LP, Flier JS. 1993. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366:740-2.
  46. Kozak UC, Kopecky J, Teisinger J, Enerback S, Boyer B, Kozak L. 1994. An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene. Mol Cell Biol 14:59-67.
  47. Kozak UC, Kozak LP. 1994. Norepinephrine-dependent selection of brown adipocyte cell lines. Endocrinology 134:906-13.
  48. Rohlfs EM, Daniel KW, Premont RT, Kozak LP, Collins S. 1995. Regulation of the uncoupling protein gene (Ucp) by B1, B2 and B3-adrenergic receptor subtypes in immortalized brown adipose cell lines. J Biol Chem 270:10723-32.
  49. Kopecky J, Clarke G, Enerback S, Spiegelman B, Kozak LP. 1995. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 96:2914-2923.
  50. Kopecky J, Hodny Z, Rossmeisl M, Syrovy I, Kozak LP. 1996. Reduction of dietary obesity in the aP2-Ucp transgenic mice: physiology and adipose tissue distribution. Am J Physiol 270:E768-E775.
  51. Koza RA, Kozak UC, Brown LJ, Leiter EH, MacDonald MJ, Kozak LP. 1996. Sequence and tissue-dependent RNA expression of mouse FAD-linked glycerol-3-phosphate dehydrogenase. Arch Biochem Biophys 336:97-104.
  52. Enerback S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper M-E, Kozak LP. 1997. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387:90-94.
  53. Ackerman SL, Kozak LP, Przyborski SA, Rund LA, Boyer BB, Knowles BB. 1997. The mouse rostral cerebellar malformation gene encodes an UNC-5 like protein. Nature 386:838-842.
  54. Nuglozeh E, Kozak LP. 1997. Genetic mapping of C-type natriuretic peptide receptor (Npr2) gene to mouse chromosome 4. Mammalian Genome 8:624-625.
  55. Tvrdik P, Asadi A, Kozak LP, Nedergaard J, Cannon B, Jacobsson A. 1997. Cig30, a mouse member of a novel plasma membrane protein gene family, is involved in the recruitment of brown adipose tissue. J Biol Chem 272:31738-31746.
  56. Guerra C, Koza R, Yamashita H, King KW, Kozak LP. 1998. Emergence of brown adipocytes in white fat is under genetic control. Effects on body weight and adiposity. J Clin Invest 102:412-420.
  57. Guerra C, Koza RA, Walsh K, Kurtz DM, Wood PA, Kozak LP. 1998. Abnormal nonshivering thermogenesis in mice with inherited defects of fatty acid oxidation. J Clin Invest 102: 1724-1731.
  58. Monemdjou S, Kozak LP, Harper M-E.. 1999. Mitochondrial proton leak in brown adipose tissue mitochondria of UCP1 knockout mice is GDP-insensitive. Am. J. Physiol 276:E1073-1082.
  59. Tvrdik P, Asadi A, Kozak LP, Nuglozeh E, Parente F, Nedergaard J, Cannon B, Jacobsson A. 1999. Cig30 and Pit3 genes are arranged in a partially overlapping tail-to-tail array in complementary transcripts. J Biol Chem 274:26387-26392.
  60. Da-Wei Gong, Shadi Monemdjou, Oksana Gavrilova, Lisa R. Leon, Bernice Marcus-Samuels, Chieh J. Chou, Carrie Everett, Leslie P. Kozak, Cuiling Li, Chuxia Deng, Mary-Ellen Harper, Marc L. Reitman. 2000 Lack of Obesity and Normal Response to Fasting and Thyroid Hormone in Mice Lacking Uncoupling Protein-3. J Biol. Chem 275: 16251-16257.
  61. Monemdjou S, Hoffmann WE, Kozak LP, Harper, M-E. 1999 Increased mitochondrial proton leak in skeletal muscle mitochondria of UCP1-deficient mice. Am J Physiol 276(6 Pt 1):E1073-82.
  62. Koza RA, Hohmann SM, Guerra C, Rossmeisl M and Kozak LP. 2000 Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue. J Biol Chem 275(44):34486-92.
  63. Kozak LP, Harper M-E. 2000. Mitochondrial uncoupling proteins in energy expenditure. Annu Rev Nutrition 20:339-63.
  64. Monemdjou S, Kozak LP, Harper, M-E. 2000 Increased mitochondrial proton leak in skeletal muscle mitochondria of UCP1-deficient mice. Am J Physiol. Endocrinol Metab. 279(4):E941-6.
  65. Gong DW, Monemdjou S, Gavrilova O, Leon LR, Marcus-Samuels B, Chou CJ, Everett C, Kozak LP, Li C, Deng C, Harper ME, Reitman ML. 2000 Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem. 275(21):16251-7.
  66. Hofmann WE, Liu X, Bearden CM, Harper ME, Kozak LP. 2001. Effects of genetic background on thermoregulation and fatty acid-induced uncoupling of mitochondria in UCP1-deficient mice. J Biol Chem 276(15):12460-5.
  67. Guerra C, Navarro P, Valverde AM, Arribas M, Bruning J, Kozak L P, Kahn C R, Benito M. Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype. 2001 J Clin Invest 108: 1205-1213.
  68. Saint-Marc P, Kozak LP, Ailhaud G, Darimont C, Negrel R. 2001 Angiotensin II as a trophic factor of White adipose tissue: Stimulation of adipose tissue formation. Endocrinology 142: 487-492.
  69. Bezaire V, Hofmann W, Kramer JKG, Kozak LP, and Harper M-E. 2002 Effects of fatsting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3 (-/-) and wild-type mice. Am J Physiol 281:E975-82.
  70. Kozak LP, and Rossmeisl M. 2002. Adiposity and the development of diabetes in mouse genetic models. Ann NY Acad Sci 967, 1-8.
  71. Brown LJ, Koza RA, Everett C, Reitman ML, Marshall L, Fahien LA, Kozak LP, and MacDonald MJ. 2002. Normal thyroid thermogenesis, but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenase. J Biol Chem 277:32892-32898.
  72. Brown LJ, Koza RA, Marshall L, Kozak LP, and MacDonald MJ. 2002. Lethal hypoglycemic ketosis and glyceroluria in mice lacking both the mitochondrial and the cytosolic glycerol phosphate dehydrogenases. J Biol Chem 277:32899-32904.
  73. Rim JS, and Kozak LP. 2002. Regulatory motifs for CREB and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein. J Biol Chem 277:34589-34600.
  74. Liu X, Rossmeisl M, McClaine J, Riachi M, Harper M-E and Kozak LP. 2003. Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J. Clin. Invest. 111:399-407.
  75. Coulter A, Bearden CM, Liu X, Koza RA, and Kozak LP. 2003. Dietary fat interacts with QTLs controlling induction of Pgc1α and Ucp1 during brown fat induction. Physiol. Genomics 14: 139-147.
  76. Rossmeisl M, Rim JS, Koza RA, and Kozak LP. 2003. Variation in type 2 diabetes-related traits in mouse strains susceptible to diet-induced obesity. Diabetes 52: 1958-1966.
  77. Rousset S, AlvespGuerra M-C, Ouadghiri-Bencherif S, Kozak LP, Miroux B, Richard D, Bouillaud F, Ricquier D, and Cassard-Doulcier A-M. 2003. UCP2 is expressed in the female mice reproductive tract whereas UCP1 is not. J. Biol.Chem. 278:45843-45847.
  78. Rim JS, Xue B, Gawronska-Kozak B, and Kozak LP. 2004. Sequestration of thermogenic transcription factors in the cytoplasm during development of brown adipose tissue. J. Biol. Chem. 279:25916-25926.
  79. Koza RA, Flurkey K, Graunke DM, Brun C, Pan HJ, Reifsnyder PC, Kozak LP, and Leiter EH. 2004. Contributions of dysregulated energy metabolism to type 2 diabetes development in NZO/H1Lt mice with polygenic obesity. Metabolism 53:799-808.
  80. Xue B, Coulter A, Rim JS, Koza RA, and Kozak LP. 2005. Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. Mol. Cell. Biol. 25:8311-8322.
  81. Nedergaard J, Ricquier D, and Kozak LP. 2005. Uncoupling proteins: current status and therapeutic prospects. EMBO Rep 6:917-921.
  82. Koza RA, Nikonova L, Hogan J, Rim JS, Mendoza T, Faulk C, Skaf J and Kozak LP. 2006. Changes in Gene Expression Foreshadow Diet-Induced Obesity in Genetically Identical Mice. PLoS Genetics 2:e81.
  83. Ukropec J, Anunciado RVP, Ravussin Y, and Kozak LP. 2006. Leptin is required for uncoupling protein-1-independent thermogenesis during cold stress. Endocrinology 147:2468-2480.
  84. Ukropec J, Anunciado RP, Ravussin Y, Hulver MW, and Kozak LP. 2006. UCP1-independent thermogenesis in white adipose tissue of cold-acclimated Ucp1-/-mice. J Biol Chem 281:31894-31908.
  85. Xue B, Rim JS, Hogan JC, Coulter AA, Kozak RA, and Kozak LP. 2006. Genetic variability affects the development of brown adipocytes in white fat, but not in interscapular brown fat. J Lipid Res 48:41-51.
  86. Anunciado-Koza R, Ukropec J, Koza RA and Kozak LP. 2008. Inactivation of UCP1 and the Glycerol Phosphate Cycle Synergistically Increase Energy Expenditure to Resist Diet-Induced Obesity. J Biol Chem 283:27688-27697.
  87. Nikonova L, Koza RA, Mendoza T, Chao PM, Curley JP, and Kozak LP. 2008. Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance. FASEB J 22:3925-3937.
  88. Kozak LP and Anunciado-Koza R. 2008. UCP1: its involvement and utility in obesity. Intl. J. Obesity 32:S32-S38.
  89. Ravussin E, and Kozak LP. 2009. Have we entered the brown adipose tissue renaissance? Obes Rev 10:265-268.
  90. Koza RA, Rogers P and Kozak LP. 2009. Inter-individual variation of dietary fat-induced mesoderm specific transcript in adipose tissue within inbred mice is not caused by altered promoter methylation. Epigenetics 4:512-518.
  91. Butler AA, and Kozak LP. 2010. A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes. Diabetes 59:323-329.
  92. Kozak, LP. 2010. Brown Fat and the myth of diet-induced thermogenesis. Cell Metab 11:263-267.
  93. Kozak LP, Newman S, Chao P-M, Mendoza T and Koza RA. 2010. The Early Nutritional Environment of the Mouse Determines the Capacity for Adipose Tissue Expansion by Modulating Genes of Caveolae Structure. PLoS ONE 5(6): e11015.
  94. Anunciado-Koza RP, Zhang J, Ukropec, J, Bajpeyi S, Koza RA, Rogers RC, Cefalu WT, Mynatt Rl, and Kozak LP. 2011. Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice. J Biol Chem 286:11659-11671.


  1. Kozak LP.  1978.  An analysis of differentiation in coaggregation cultures between mouse neuronal and tumor cells.  In:  Genetic Mosaics and Chimeras in Mammals, Russell L (ed), Plenum Press, New York.
  2. Bignami A, Kozak LP, Dahl D.  1980.  Molecular markers for the analysis of neuronal differentiation in culture.  In:  Tissue Culture in Neurobiology.  Proceedings of the Bat-Sheva Satellite Symposium on Development of Nervous Tissue Culture, Raven Press.
  3. Kozak LP.  1985.  Genetic variation in catecholmine responsive metabolic pathways-a hypothesis for a common regulatory mechanism in Balb/c sublines.  In:  Balb/c Mouse, Potter M (ed), Genetics and Immunology, Springer-Verlag, Berlin, pp. 66-70.
  4. Kozak LP, Fisher M.  1985.  The molecular genetic analysis of sn-glycerol-3-phosphate dehydrogenase development in mouse cerebellum.  In:  Gene Expression in the Brain, Zomzely-Neurath C et al. (eds), John Wiley & Sons, Inc.
  5. Kozak LP, Kozak U, Jerry J, Wells J.  1990.  The glycerol-3-phosphate dehydrogenase gene: analysis of a complex structural domain and a null mutant.  In:  Obesity:  Towards a Molecular Approach.  UCLA Symposia on Molecular and Cellular Biology.  Alan Liss, Inc., pp. 263-72.
  6. Kozak LP.  1996.  Manipulating the mouse germline:  implications for obesity research.  In:  Regulation of Body Weight:  Biological and Behavioral Mechanisms, Bouchard C, Bray GA (eds), Dahlem Workshop on Body Weight Biological and Behavioral Mechanisms, Berlin. John Wiley & Sons Ltd., pp. 271-282.
  7. Kozak LP, Kozak UC, Clarke G, Enerback S, Kopecky J.  1996.  Genes of Energy Balance:  Modulation in Transgenic Mice.  In:  Molecular and Genetic Aspects of Obesity, Bray G, Ryan DH (ed), LSU Press, Baton Rouge, Louisiana.  Pennington Center Nutrition Series, Vol. 5, pp. 609-623.
  8. Warden CH, Bouchard C, Friedman JM, Hebebrand J, Hitman GA, Kozak LP, Leibel RL, Price RA, Zechner R.  1996.  Group report:  How can we best apply the tools of genetics to study body weight regulation?  In: Regulation of Body Weight:  Biological and Behavioral Mechanisms, Bouchard C, Bray GA (eds), Dahlem Workshop on Body Weight Biological and Behavioral Mechanisms, Berlin.  John Wiley & Sons Ltd., pp. 285-305.
  9. Kozak LP.  1997.  Reawakening brown adipose tissue:  a strategy for enhancing energy expenditure.  In:  Obesity II.  Recent Advances in Understanding and Treatment, Thibeault CA (ed), IBC Library Series, pp. 233-248.
  10. Kozak LP, Guerra C, Koza R.  1999.  The mitochondrial uncoupling protein (UCP1) in brown adipose tissue.  In: Pennington Center Nutrition series,  Vol 9, pp 88-101.
  11. Kozak LP and Koza RA.  1999 Mitochondrial uncoupling proteins and obesity: Molecular and genetic aspects of UCP1. International J. Obesity 23, 1-5.
  12. Kozak LP, Koza RA, Liu X. 2000. Exploring a role for brown fat in the regulation of body weight. Volume 37,Proceedings of the Steenbock Symposium on Adipocyte Biology and Hormonal Signalling, pp 117-125.
  13. Kozak LP, Harper M-E. 2000. Mitochondrial uncoupling proteins in energy expenditure.  Ann Rev Nutrition 20: 339-363.
  14. Kozak, LP.  2000.  Genetic studies of brown adipocyte induction.  J Nutr 130(12):3132S-133S.
  15. Kozak LP.  2000.  Uncoupling diet and diabetes.  Nat Med.  6(10):1092-3.
  16. Ricquier, D, Kozak LP.  2004. Uncoupling Proteins in Handbook of Obesity. Edited by George Bray and Claude Bouchard Marcel Decker, New York .
  17. Ravussin, E, Kozak, LP.  2003.  Energy Homeostatis in Pharmacotheraphy of Obesity.  Editor--Karl G. Hofbauer.
  18. Ravussin, E, Kozak, LP.  2003.  Chapter 37:  The Role of Energy Expenditure in the Regulation of Energy Balance in International Textbook of Diabetes, 3rd Edition.
  19. Kozak, LP., Nedergaard, J. Ricquier, D. 2005. Uncoupling proteins: current status and      therapeutic prospects. EMBO Reports 6:917-21.
  20. Ravusssin, E, Kozak, LP. 2009. Have we entered the brown adipose tissue renaissance? Obesity Reviews 10, 265-268.
  21. Kozak LP, Koza, RA and Anunciado-Koza, R. 2010. Brown fat thermogenesis and body weight regulation in mice: Relevance to humans in Proceedings of the 11th Annual International Symposium in Obesity, “Rediscovering Brown Adipose Tissue,” Intl. J. Obesity 34:S23-S27.
  22. Kozak LP and Koza RA. 2010.” The Genetics of Brown Adipose Tissue” in Genes and Obesity, in Progress in Molecular Biology and Translational Science, edited by Claude Bouchard, Elsevier Vol. 94: 75-123.


During my 29 years as a faculty member at the Jackson Laboratory, my research program was entirely supported by research grants from the NIH, from Pfizer Inc. and Glaxo-Wellcome Inc.  Since there was no institutional salary provided by the Jackson Laboratory, except for short periods of interim support when a grant application was not successful, all of my salary was funded from external grant funds.  During my tenure at the Pennington , except for partial salary support from the Claude Bernard Chair in Molecular Genetics, my salary was provided by research grants and State support.



Kozak, Leslie P. Foundation for Polish Science. Supplemental Funding for Project and Recipient’s Stipend in Welcome programme /2010-4/3, Nutritional and ambient temperature during early development can reduce susceptibility to obesity, 7,225,062.85 PLN, 06-2011 to 05-2015.