Discovering The Developmental Origins of Obesity

The Polish Academy of Sciences in Olsztyn, Poland


Modulation of metabolic efficiency and gut microbial community by ambient temperature

Manipulations of ambient temperature constitute an efficient strategy in the regulation of energy metabolism. Lower ambient temperature is able to increase energy expenditure by evoking a thermogenic response. As a consequence the reduced metabolic efficiency diminishes the propensity to become obese.

A restricted capacity of primary cultures of ear mesenchymal stem cells to differentiate to adipocytes

tn Toi and Ela POSTER edit lpk BGK May Toi revised May 06INTRODUCTION
One major goal of current research in brown adipose tissue (BAT) biology is to determine the molecular basis for its variable induction in white fat depots. The expression of BAT in white fat depends on developmental age, genotype and specific white fat depot. We have been testing the conditions for culturing the stromal vascular fraction (SVF) from inguinal fat (ingWAT), interscapular brown fat (iBAT) and ear mesenchymal stem cells (EMSC) to ascertain conditions for maximal expression of biomarkers for the brown and white differentiation programs.

Impact of reduced ambient temperature during early post-natal development on diet-induced obesity in adult mice

tn poster Liverpool green results LPKABSTRACT
Dietary conditions that vary energy intake during early postnatal development will impact body composition phenotypes in adult life. We predicted that changes in energy balance by modulating energy expenditure during the early post-natal period will also affect adiposity phenotypes. To test this idea, we investigated the effects of different ambient temperatures during early development on high fat diet-induced obesity in adult mice. AXB8 and C57BL/6J male mice, representing mice with low (C57BL/6J) and high (AXB8) induction brown adipocytes in white fat, were maintained from birth to weaning at either 17°C or 29°C and fed a standard chow diet (STD, 11 kcal% fat). At weaning animals were maintained at 23°C until the end of the protocol and from the 8th to 16th week of life they were fed a high fat diet (HFD, 58 kcal% fat).

Prof. Kozak’s work in Nature Medicine

tn prof l kozakProf. Leslie Kozak working in IAR&FR within the framework of the REFRESH project published his work in the October issue of Nature Medicine journal.

Nature Medicine is the premier journal for biomedical research. The 2011 impact factor for Nature Medicine is 22.462, according to the Thomson Reuters Journal Citation Reports. This places Nature Medicine as the top primary research journal in Medicine (Research and Experimental).

Prof. Kozak’s work entitled “Heat from calcium cycling melts fat” elaborates upon the possibilities of the use of uncoupling proteins responsible for thermoregulation in the organism.


Meeting a Men with Passion

tn l kozak mwkProfessor Leslie Kozak will meet with students from Olsztyn grammar schools within the series of "Meetings with people with a passion" organized by the Academy of Young Nobel Prize Winners, as a world class researcher.  

Dates of the meetings:

The meetings will take place on April 12 at 10.00 a.m. (Jan Paweł II Grammar School no. 2  in Kętrzyn, Irena Sendlerowa Grammar School in Sępopol).

And on April 19 at 10.00 a.m.(School Complex in Młynary, Jan Paweł II Public Grammar School in Pieniężno).



We are very happy to announce that Dr. Gawrońska-Kozak’s article titled “Scarless skin wound healing in FOXN1 deficient (nude) mice is associated with distinctive matrix metalloproteinase expression”, published in Matrix Biology as one of new original discoveries and insights, has appeared on the list of 25 most downloaded articles for 2011 from Elsevier's SciVerse Sciencedirect - the world's leading source for scientific, technical, and medical full text research.