Discovering The Developmental Origins of Obesity

The Polish Academy of Sciences in Olsztyn, Poland


Inactivation of Sca-1 does not protect mice from diet-induced obesity

tn Barbara Kozak Keystone 2012 posterINTRODUCTION
Stem Cell Antigen-1 (Sca-1), a surface protein initially identified as an antigenic marker of murine hematopoietic cells, is commonly used for the identification of stem cells in various tissues. A substantial body of literature links stem cell antigen-1 (SCA-1) to stem cell function in adipose tissue.
In the present study we hypothesize that SCA-1 is a biomarker for adipocyte stem/progenitor cells within adipose tissue and that SCA-1 is required for adipose tissue expansion in an obesogenic environment.