Discovering The Developmental Origins of Obesity

The Polish Academy of Sciences in Olsztyn, Poland


Effects of rearing temperature and diet on susceptibility to adiposity in wild-type and UCP1-deficient mice

tn EMBO meeting poster ZuliaINTRODUCTION
Environmental conditions during early postnatal life exert long lasting effects by establishing a stable phenotype extending into adulthood. Alteration in developmental plasticity in response to environmental cues such as nutritional status or ambient temperature may lead to obesity in later life. Previous work demonstrated that UCP1-deficiency in adult mice is associated with resistance to diet-induced obesity (DIO) when the ambient temperature is below thermoneutral (28°C), by forcing an animal to activate alternative and less efficient thermogenic pathways (Liu et al., 2003; Anunciado-Koza et al., 2008). Others have found that UCP1-deficient mice are more susceptible to DIO when maintained at thermoneutrality (Feldmann et al., 2009).