Discovering The Developmental Origins of Obesity

The Polish Academy of Sciences in Olsztyn, Poland

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Impact of reduced ambient temperature during early post-natal development on diet-induced obesity in adult mice

tn poster Liverpool green results LPKABSTRACT
Dietary conditions that vary energy intake during early postnatal development will impact body composition phenotypes in adult life. We predicted that changes in energy balance by modulating energy expenditure during the early post-natal period will also affect adiposity phenotypes. To test this idea, we investigated the effects of different ambient temperatures during early development on high fat diet-induced obesity in adult mice. AXB8 and C57BL/6J male mice, representing mice with low (C57BL/6J) and high (AXB8) induction brown adipocytes in white fat, were maintained from birth to weaning at either 17°C or 29°C and fed a standard chow diet (STD, 11 kcal% fat). At weaning animals were maintained at 23°C until the end of the protocol and from the 8th to 16th week of life they were fed a high fat diet (HFD, 58 kcal% fat).